Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CCKBR | P32239 | 10/20 | 0.51 |
| ▸ | CCKAR | P32238 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837578 | 0.95 | KCNH2 (0.55) | KCNH2CCKBRCCKARHDAC3HDAC4 | |
| SCHEMBL9257270 | 0.92 | KCNH2 (0.52) | KCNH2CCKBRCCKAR | |
| SCHEMBL8837719 | 0.88 | KCNH2 (0.70) | KCNH2CCKBRCCKARHDAC3HDAC4 | |
| SCHEMBL9286936 | 0.87 | KCNH2 (0.63) | KCNH2CCKBRCCKARHDAC3HDAC4 | |
| SCHEMBL8837675 | 0.86 | KCNH2 (0.57) | KCNH2CCKBRCCKARHDAC3HDAC4 | |
| SCHEMBL9269301 | 0.85 | KCNH2 (0.57) | KCNH2CCKBRCCKARHDAC3HDAC4 | |
| SCHEMBL8745310 | 0.80 | KCNH2 (0.73) | KCNH2CCKBRCCKARHDAC3HDAC4 | |
| SCHEMBL7170310 | 0.78 | HDAC3 (0.76) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL8608841 | 0.78 | HDAC3 (0.76) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL8745122 | 0.77 | HDAC3 (0.58) | KCNH2CCKBRCCKARHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730453-A4 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0730584-A4 | 3-ACYLAMINOBENZODIAZEPINES | MERCK & CO INC (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5597818-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-28 | — | — | US | disclosed |
| EP-0730584-A1 | 3-ACYLAMINOBENZODIAZEPINES | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0730453-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5428031-A | Benzodiazepine analogs; cardiovascular disorders | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5428157-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| WO-1995014676-A1 | 3-ACYLAMINOBENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| WO-1995014470-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |