Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862747 | 0.94 | CYP2C8 (0.44) | CYP2C8IDH1KMT2AECE1AGTR1 | |
| SCHEMBL862574 | 0.90 | CYP2C8 (0.41) | CYP2C8KMT2AECE1PTGDR2MAPT | |
| SCHEMBL862344 | 0.88 | CYP2C8 (0.43) | CYP2C8KMT2AFABP5PTGDR2MAPT | |
| SCHEMBL831554 | 0.88 | CYP2C8 (0.47) | CYP2C8KMT2APTGDR2MAPTPOLB | |
| SCHEMBL832758 | 0.86 | CYP2C8 (0.41) | CYP2C8KMT2AECE1PTGDR2MAPT | |
| SCHEMBL862454 | 0.85 | CYP2C8 (0.39) | CYP2C8KMT2AMAPTFLT1FLT4 | |
| SCHEMBL832763 | 0.84 | CYP2C8 (0.42) | CYP2C8KMT2APTGDR2MAPTPOLB | |
| SCHEMBL862329 | 0.84 | PPARG (0.40) | CYP2C8KMT2AFLT1FLT4KDR | |
| SCHEMBL832426 | 0.84 | CYP2C8 (0.43) | CYP2C8IDH1KMT2APTGDR2MAPT | |
| SCHEMBL832380 | 0.84 | CYP2C8 (0.43) | CYP2C8IDH1KMT2AECE1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | CYP2C8 847/4885IDH1 1781/4885KMT2A 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.