Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 3/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620033 | 0.88 | S1PR1 (0.40) | FDFT1S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL8623396 | 0.85 | FFAR1 (0.45) | FDFT1PPARGPPARA | |
| SCHEMBL8947010 | 0.83 | S1PR1 (0.36) | S1PR1S1PR4S1PR5S1PR3S1PR2 | |
| SCHEMBL8624761 | 0.82 | S1PR1 (0.44) | FDFT1S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL8624038 | 0.79 | FDFT1 (0.57) | FDFT1PPARG | |
| SCHEMBL8622881 | 0.79 | FDFT1 (0.34) | FDFT1S1PR1S1PR4S1PR3S1PR2 | |
| SCHEMBL8622877 | 0.79 | FDFT1 (0.34) | FDFT1S1PR1S1PR4S1PR3S1PR2 | |
| SCHEMBL8625395 | 0.78 | POLB (0.44) | FDFT1 | |
| SCHEMBL8620506 | 0.78 | S1PR1 (0.50) | FDFT1S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL8619968 | 0.78 | POLB (0.47) | FDFT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |