Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 14/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627047 | 1.00 | GRIA2 (0.56) | GRIA2GRIA1GRIA3GRIA4JAK2 | |
| SCHEMBL2776314 | 0.76 | GRIA2 (0.87) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2776216 | 0.76 | GRIA2 (0.87) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2779056 | 0.76 | GRIA2 (0.87) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2775051 | 0.74 | GRIA2 (0.89) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL8561528 | 0.74 | GRIA2 (0.50) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL2777251 | 0.73 | GRIA2 (0.62) | GRIA2GRIA1GRIA3GRIA4KDM4E | |
| SCHEMBL2776022 | 0.73 | GRIA2 (0.62) | GRIA2GRIA1GRIA3GRIA4KDM4E | |
| SCHEMBL2775610 | 0.73 | GRIA2 (0.62) | GRIA2GRIA1GRIA3GRIA4KDM4E | |
| SCHEMBL2775511 | 0.73 | GRIA2 (0.62) | GRIA2GRIA1GRIA3GRIA4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |