Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625461 | 1.00 | LSS (0.39) | LSSPOLBMEN1KMT2AALOX5 | |
| SCHEMBL8626302 | 0.94 | TRPV1 (0.38) | LSSPOLBMEN1KMT2ATRPV1 | |
| SCHEMBL8626297 | 0.94 | TRPV1 (0.38) | LSSPOLBMEN1KMT2ATRPV1 | |
| SCHEMBL8622877 | 0.88 | FDFT1 (0.34) | — | |
| SCHEMBL8622881 | 0.88 | FDFT1 (0.34) | — | |
| SCHEMBL8622789 | 0.86 | S1PR2 (0.41) | LSSMAPTRXFP1 | |
| SCHEMBL8622799 | 0.86 | S1PR2 (0.41) | LSSMAPTRXFP1 | |
| SCHEMBL8619968 | 0.84 | POLB (0.47) | POLBMEN1KMT2AGAA | |
| SCHEMBL8624092 | 0.82 | LSS (0.40) | LSS | |
| SCHEMBL8624098 | 0.82 | LSS (0.40) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |