Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 14/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628854 | 0.90 | HTT (0.49) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL6567430 | 0.90 | PTGER1 (0.52) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL6565684 | 0.86 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL27610351 | 0.86 | PTGER1 (0.43) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL1508856 | 0.83 | KMT2A (0.47) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL6567431 | 0.81 | PTGER1 (0.47) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL6567174 | 0.80 | GAA (0.45) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL8629304 | 0.80 | PTGER1 (0.52) | HTTSMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL8629531 | 0.79 | MRGPRX4 (0.44) | HTTSMN1; SMN2STAT3MRGPRX4 | |
| SCHEMBL18864507 | 0.78 | PLAU (0.55) | SMN1; SMN2MAPTL3MBTL1PTGER1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |