Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1501319 | 0.88 | SMN1; SMN2 (0.63) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL14393266 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL9489957 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL5787835 | 0.82 | HPGD (0.51) | KMT2ARAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL27918588 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL9650619 | 0.82 | KMT2A (0.48) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL28560101 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL6790464 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL608814 | 0.81 | ABL1 (0.68) | SMN1; SMN2TSHRCASP1MAPTKMT2A | |
| SCHEMBL6790467 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRCASP1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5795905-A | 3-AMINO-5-PHENYL-1,2,4-TRIAZOLES | NEUROCRINE BIOSCIENCES, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0846108-A1 | AMINO-SUBSTITUTED THIADIAZOLES, PYRIMIDINES, TRIAZINES OR TRIAZOLES USEFUL AS CTF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996039400-A1 | AMINO-SUBSTITUTED THIADIAZOLES, PYRIMIDINES, TRIAZINES OR TRIAZOLES USEFUL AS CTF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 1996-12-12 | — | — | WO | disclosed |