Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 17/20 | 0.87 |
| ▸ | HTR1A | P08908 | 16/20 | 0.87 |
| ▸ | HTR1D | P28221 | 14/20 | 0.87 |
| ▸ | MAPT | P10636 | 2/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.87 |
| ▸ | TP53 | P04637 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 1/20 | 0.87 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.85 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.85 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL3115180 | 1.00 | HTR1B (0.87) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL8631086 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL17402426 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL8628236 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL17402421 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14907322 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL8624139 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14907348 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14907353 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL14907325 | 0.93 | HTR1B (1.00) | HTR1BHTR1AHTR1DMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666847-B1 | TRYPTAMINE ANALOGS WITH 5-HT1D SELECTIVITY | ALLELIX BIOPHARMA (CA) | 1998-06-17 | — | — | EP | disclosed |
| US-5496957-A | 5-HYDOXYTRYPTAMINE | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0666847-A1 | TRYPTAMINE ANALOGS WITH 5-HT1D SELECTIVITY | Allelix Biopharmaceuticals Inc. (CA) | 1995-08-16 | — | — | EP | disclosed |
| WO-1995006638-A1 | TRYPTAMINE ANALOGS WITH 5-HT1D SELECTIVITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1995-03-09 | — | — | WO | disclosed |