Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CCKBR | P32239 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7873659 | 0.99 | KDM4E (0.50) | KDM4EALDH1A1GAAMAPK1ITGB3 | |
| Hydrochloric Acid SCHEMBL7881224 | 0.90 | KDM4E (0.48) | KDM4EALDH1A1GAAMAPK1ITGB3 | |
| SCHEMBL7882001 | 0.87 | KDM4E (0.50) | KDM4EALDH1A1GAAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL8628148 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7873573 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7881094 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7879984 | 0.85 | AR (0.50) | KDM4EALDH1A1GAAMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL7873315 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1GAAMAPK1MAPT | |
| SCHEMBL8628054 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1GAAMAPK1ITGB3 | |
| Hydrochloric Acid SCHEMBL7881081 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1GAAMAPK1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0622356-B1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMA (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0622356-A1 | Indoloylguanidine derivatives as inhibitors of sodium-hydrogen exchange | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-02 | — | — | EP | disclosed |