Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 11/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 9/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 9/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 9/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 9/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902983 | 0.92 | GRIN1 (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8902212 | 0.89 | GRIN2D (0.42) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8903252 | 0.78 | GRIN1 (0.59) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7784735 | 0.75 | GRIN1 (0.56) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL4707795 | 0.74 | GRIN2D (0.69) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7784707 | 0.72 | GRIN1 (0.47) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL4705554 | 0.71 | GRIN1 (0.55) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL2639582 | 0.69 | GRIN2D (0.58) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL462740 | 0.69 | GRIN2D (0.61) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL8902826 | 0.69 | GRIN2D (0.50) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000124-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | WEBER ECKARD (US) | 1994-01-06 | — | — | WO | disclosed |