Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | RARA | P10276 | 4/20 | 0.31 |
| ▸ | RARB | P10826 | 4/20 | 0.31 |
| ▸ | RARG | P13631 | 4/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.31 |
| ▸ | RXRB | P28702 | 2/20 | 0.31 |
| ▸ | RXRG | P48443 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7684814 | 1.00 | MAPT (0.51) | MAPTALOX15CYP1A2HAO1RXRA | |
| SCHEMBL7827749 | 0.94 | MAPT (0.52) | MAPTALOX15CYP1A2HAO1 | |
| SCHEMBL956693 | 0.80 | MAPT (0.62) | MAPTALOX15CYP1A2HAO1RXRA | |
| SCHEMBL9840329 | 0.79 | MAPT (0.58) | MAPTALOX15CYP1A2HAO1RXRA | |
| SCHEMBL9840327 | 0.79 | MAPT (0.58) | MAPTALOX15CYP1A2HAO1RXRA | |
| SCHEMBL14181272 | 0.77 | MAPT (0.67) | MAPTALOX15CYP1A2RXRAALDH1A1 | |
| SCHEMBL8390312 | 0.76 | MAPT (0.67) | MAPTALOX15CYP1A2HAO1RXRA | |
| SCHEMBL8390315 | 0.76 | MAPT (0.67) | MAPTALOX15CYP1A2HAO1RXRA | |
| SCHEMBL11423435 | 0.75 | MAPT (0.60) | MAPTALOX15CYP1A2RXRAALDH1A1 | |
| SCHEMBL13542774 | 0.75 | MAPT (0.56) | MAPTALOX15CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750758-A | DEHYDRATION OF CARBONIC ACID | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |