Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637840 | 0.95 | SCN9A (0.56) | SCN9ASCN3AFAAHMAOBMAOA | |
| SCHEMBL963780 | 0.89 | SCN9A (0.73) | SCN9ASCN3AMAOBPARP15PARP14 | |
| SCHEMBL9133470 | 0.86 | FFAR1 (0.54) | — | |
| SCHEMBL8637430 | 0.85 | SCN9A (0.79) | SCN9ASCN3AMAOBMAOA | |
| SCHEMBL8640727 | 0.85 | SCN9A (0.79) | SCN9ASCN3AMAOBMAOA | |
| SCHEMBL8637844 | 0.85 | SCN9A (0.54) | SCN9ASCN3AFAAHMAOBMAOA | |
| SCHEMBL8637538 | 0.83 | MAOB (0.58) | SCN9AMAOBMAOA | |
| SCHEMBL7138716 | 0.81 | FFAR1 (0.49) | — | |
| SCHEMBL8634600 | 0.80 | SCN9A (0.81) | SCN9ASCN3AMAOBMAOA | |
| SCHEMBL15195013 | 0.79 | SCN9A (0.76) | SCN9ASCN3AMAOBPARP15PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643688-B1 | SUBSTITUTED (ARYLALKOXYBENZYL)AMINOPROPANAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-EPILEPTIC, NEUROPROTECTIVE AND ANTIDEPRESSANT AGENTS | PHARMACIA & UPJOHN SPA (IT) | 1998-07-29 | — | — | EP | claimed |
| US-5446066-A | Antiepileptic, antidepressants, antispastic agent | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-08-29 | — | — | US | claimed |
| EP-0643688-B1 | SUBSTITUTED (ARYLALKOXYBENZYL)AMINOPROPANAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-EPILEPTIC, NEUROPROTECTIVE AND ANTIDEPRESSANT AGENTS | PHARMACIA & UPJOHN SPA (IT) | 1998-07-29 | — | — | EP | disclosed |
| US-5446066-A | Antiepileptic, antidepressants, antispastic agent | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-08-29 | — | — | US | disclosed |