Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655194 | 1.00 | ATM (0.58) | ATMCYP19A1GRM1POLBPDE4A | |
| SCHEMBL8636425 | 1.00 | ATM (0.58) | ATMCYP19A1GRM1POLBPDE4A | |
| SCHEMBL2654180 | 0.89 | ATM (0.46) | ATMCYP19A1GRM1POLB | |
| SCHEMBL3073477 | 0.84 | ATM (0.59) | ATMCYP19A1GRM1POLBEPHX2 | |
| SCHEMBL7442862 | 0.83 | ATM (0.62) | ATMCYP19A1GRM1POLBPDE4A | |
| SCHEMBL13740309 | 0.83 | ATM (0.62) | ATMCYP19A1GRM1POLBPDE4A | |
| SCHEMBL2623615 | 0.81 | ATM (0.56) | ATMCYP19A1GRM1 | |
| SCHEMBL3083578 | 0.81 | ATM (0.56) | ATMCYP19A1GRM1POLBPDE4A | |
| SCHEMBL22592072 | 0.81 | ATM (0.56) | ATMCYP19A1GRM1POLBPDE4A | |
| SCHEMBL15219695 | 0.81 | ATM (0.56) | ATMCYP19A1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748312-B1 | BICYCLIC CARBAMATES AS LEUKOTRIENE D4 ANTAGONISTS | PFIZER (US) | 1998-07-22 | — | — | EP | disclosed |
| US-5439929-A | Antagonist of leukotriene D4; blocking the leukotriene D4 receptor | PFIZER INC. (US) | 1995-08-08 | — | — | US | disclosed |