Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.78 |
| ▸ | PDE4A | P27815 | 15/20 | 0.78 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.78 |
| ▸ | TNF | P01375 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643869 | 0.93 | PDE4A (0.76) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL8640781 | 0.93 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL6553133 | 0.88 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL8326339 | 0.85 | PDE4A (0.71) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL5905223 | 0.83 | PDE4A (0.89) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL5905090 | 0.80 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL2992015 | 0.80 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL8640250 | 0.80 | PDE4A (0.84) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL6555476 | 0.80 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL14402820 | 0.78 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728845-A | TUMOR NECROSIS FACTOR AND PHOSPHODIESTERASE INHIBITORS | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | claimed |