Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Cgc-11047. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.95 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SAT1 | P21673 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.32 |
| ▸ | SMOX | Q9NWM0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cgc-11047 SCHEMBL8640375 | 1.00 | KDM1A (0.95) | KDM1ACYP2C19MEN1GLAKMT2A | |
| Cgc-11047 SCHEMBL2360444 | 0.97 | KDM1A (1.00) | KDM1ACYP2C19MEN1GLAKMT2A | |
| Cgc-11047 SCHEMBL2359741 | 0.97 | KDM1A (1.00) | KDM1ACYP2C19MEN1GLAKMT2A | |
| Cgc-11047 SCHEMBL2359734 | 0.97 | KDM1A (1.00) | KDM1ACYP2C19MEN1GLAKMT2A | |
| Cgc-11047 SCHEMBL427906 | 0.95 | KDM1A (1.00) | KDM1ACYP2C19MEN1GLAKMT2A | |
| Cgc-11047 SCHEMBL427907 | 0.95 | KDM1A (1.00) | KDM1ACYP2C19MEN1GLAKMT2A | |
| Cgc-11047 SCHEMBL2359065 | 0.95 | KDM1A (1.00) | KDM1ACYP2C19MEN1GLAKMT2A | |
| SCHEMBL13097481 | 0.92 | KDM1A (0.95) | KDM1ACYP2C19MEN1GLAKMT2A | |
| SCHEMBL12085577 | 0.92 | KDM1A (0.95) | KDM1ACYP2C19MEN1GLAKMT2A | |
| SCHEMBL13097526 | 0.90 | KDM1A (0.90) | KDM1ACYP2C19MEN1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686143-B1 | UNSATURATE AMINO COMPOUNDS FOR USE AS ANTICANCER AND ANTIPROTOZOIC AGENT | CIBA GEIGY AG (CH) | 1998-08-12 | — | — | EP | disclosed |
| US-5627215-A | Unsaturate amino compounds for use as anticancer and antiprotozoic agent | CIBA-GEIGY CORPORATION (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0686143-A1 | UNSATURATE AMINO COMPOUNDS FOR USE AS ANTICANCER AND ANTIPROTOZOIC AGENT | Novartis AG (CH) | 1995-12-13 | — | — | EP | disclosed |
| WO-1995018091-A1 | UNSATURATE AMINO COMPOUNDS FOR USE AS ANTICANCER AND ANTIPROTOZOIC AGENT | CIBA-GEIGY AG (CH) | 1995-07-06 | — | — | WO | disclosed |