Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CTSG | P08311 | 2/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | KLK14 | Q9P0G3 | 2/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | CTRC | Q99895 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640711 | 1.00 | NPC1 (0.54) | NPC1RAB9AKDM4EPOLBELANE | |
| SCHEMBL8643427 | 0.91 | KLK7 (0.54) | NPC1RAB9AKDM4EPOLBELANE | |
| SCHEMBL8643434 | 0.91 | KLK7 (0.54) | NPC1RAB9AKDM4EPOLBELANE | |
| SCHEMBL8638412 | 0.88 | NPC1 (0.62) | NPC1RAB9APOLBELANEKMT2A | |
| SCHEMBL8638406 | 0.88 | NPC1 (0.62) | NPC1RAB9APOLBELANEKMT2A | |
| SCHEMBL1589852 | 0.88 | NPC1 (0.72) | NPC1RAB9AKDM4EELANEKMT2A | |
| SCHEMBL1589854 | 0.88 | NPC1 (0.72) | NPC1RAB9AKDM4EELANEKMT2A | |
| SCHEMBL8638240 | 0.87 | KDM4E (0.51) | NPC1RAB9AKDM4EPOLBELANE | |
| SCHEMBL8638248 | 0.87 | KDM4E (0.51) | NPC1RAB9AKDM4EPOLBELANE | |
| SCHEMBL11408912 | 0.87 | NPC1 (0.52) | NPC1RAB9AKDM4EELANEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855387-A1 | 2-ACYLAMINOBENZAMIDE DERIVATIVES AND PREVENTIVE AND REMEDY FOR DISEASES CAUSED BY THE SUPERMULTIPLICATION OF VASCULAR INTIMAL CELLS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |