Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 3/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.46 |
| ▸ | CDC25B | P30305 | 5/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.45 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.45 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.44 |
| ▸ | GJB2 | P29033 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22288949 | 0.83 | TACR2 (0.52) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL7151712 | 0.82 | TACR2 (0.51) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL13956411 | 0.82 | TACR2 (0.47) | TACR2PTPN1CDC25BSSTR4SSTR1 | |
| SCHEMBL8723296 | 0.82 | NT5E (0.53) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL13956413 | 0.81 | PTPN1 (0.41) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL20473776 | 0.81 | PTPN1 (0.50) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL28516241 | 0.81 | PTPN1 (0.50) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL22288956 | 0.80 | TACR2 (0.47) | TACR2NT5EPTPN1CDC25BSSTR4 | |
| SCHEMBL30712002 | 0.80 | NT5E (0.48) | TACR2NT5EPTPN1CDC25BPTPN2 | |
| SCHEMBL9699456 | 0.79 | PDPK1 (0.44) | PTPN1SSTR4SSTR1SSTR2SSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750735-A | CHEMICAL INTERMEDIATES FOR ANTIBIOTICS | AMERICAN CYANAMID COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5744465-A | Method of inhibiting a β-lactamase enzyme by administering novel 2-thiosubstituted carbapenems | AMERICAN CYANAMID COMPANY (US) | 1998-04-28 | — | — | US | disclosed |
| US-5623081-A | USING BENZYLOXYACETALDEHYDE DIMETHYL ETHER, HALOGENATED 1-PHENYLMETHOXY-4-PENTEN-2-OL; CYCLIZATION | LIN YANG-I (US) | 1997-04-22 | — | — | US | disclosed |
| US-5602118-A | A 2-((2-SUBSTITUTED ALKYL)FUR-3-YL)-THIO-),3-CARBOXY-2-CARBOPENEM DERIVATIVES; EFFECTIVE AGAINST BETA-LACTAM ANTIBIOTIC-RESISTANT BACTERIA | AMERICAN CYANAMID COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0617036-A2 | Novel 2-thiosubstituted carbapenems | AMERICAN CYANAMID COMPANY (US) | 1994-09-28 | — | — | EP | disclosed |