Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.70 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | TNF | P01375 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650563 | 0.95 | ENPP1 (0.60) | ENPP1KDRTNFEGFRPDE3B | |
| SCHEMBL17836941 | 0.90 | ENPP1 (0.56) | ENPP1KDREGFR | |
| SCHEMBL16760460 | 0.89 | ENPP1 (0.67) | ENPP1KDRMAPK1 | |
| SCHEMBL15953550 | 0.87 | ENPP1 (0.66) | ENPP1KDRTNFEGFRMAPK1 | |
| SCHEMBL641754 | 0.85 | ENPP1 (0.63) | ENPP1KDRTNFEGFR | |
| SCHEMBL4329011 | 0.85 | ENPP1 (0.63) | ENPP1KDRTNFEGFR | |
| SCHEMBL16760358 | 0.84 | ENPP1 (0.67) | ENPP1KDRMAPK1ALDH1A1 | |
| SCHEMBL1013282 | 0.83 | ENPP1 (1.00) | ENPP1KDREGFRMAPK1ALDH1A1 | |
| SCHEMBL30591048 | 0.83 | ENPP1 (1.00) | ENPP1KDREGFRMAPK1ALDH1A1 | |
| SCHEMBL1012109 | 0.83 | ENPP1 (1.00) | ENPP1KDREGFRMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0746554-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |