⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27579555 | 0.81 | — | — | |
| SCHEMBL1224407 | 0.74 | — | — | |
| SCHEMBL2649685 | 0.74 | — | — | |
| SCHEMBL8645437 | 0.72 | — | — | |
| SCHEMBL22279950 | 0.70 | — | — | |
| SCHEMBL8924800 | 0.70 | — | — | |
| SCHEMBL19633273 | 0.69 | — | — | |
| SCHEMBL28065549 | 0.69 | — | — | |
| SCHEMBL18577618 | 0.67 | — | — | |
| SCHEMBL301651 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107295798-B | Benzazepine dicarboxamide compound | 豪夫迈·罗氏有限公司 | 2020-10-30 | — | — | CN | disclosed |
| CN-107148417-B | Benzazepine sulfonamide compounds | 豪夫迈·罗氏有限公司 | 2020-09-08 | — | — | CN | disclosed |
| EP-3233835-B1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| EP-3265458-B1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-12-19 | — | — | EP | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| EP-3265458-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2018-01-10 | — | — | EP | disclosed |
| US-9822065-B1 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-11-21 | — | — | US | disclosed |
| EP-3233835-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-9597333-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| WO-2016142250-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |
| EP-0859284-A1 | Water-developable photosensitive composition and production process thereof | Nippon Paint Co., Ltd. (JP) | 1998-08-19 | — | — | EP | disclosed |