SCHEMBL8645945

SCHEMBL8645945

O=C(O)C1CC(F)(F)CC1C(=O)OC(=O)C1CC(F)(F)CC1C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 4/20 0.40
CYP2C19 P33261 3/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GRM8 O00222 1/20 0.40
GRM6 O15303 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
SLC6A12 P48065 1/20 0.31
SLC6A11 P48066 1/20 0.31
GABRR1 P24046 1/20 0.31
APLNR P35414 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24174890 0.86 GRM4 (0.50) GRM4CYP2C19MEN1ALDH1A1CYP1A2
SCHEMBL8645692 0.86 GRM4 (0.50) GRM4CYP2C19MEN1ALDH1A1CYP1A2
SCHEMBL26377435 0.86 GRM4 (0.50) GRM4CYP2C19MEN1ALDH1A1CYP1A2
SCHEMBL26656015 0.83 GRM4 (0.38) GRM4CYP2C19MEN1ALDH1A1CYP1A2
SCHEMBL17756085 0.83 GRM4 (0.38) GRM4CYP2C19MEN1ALDH1A1CYP1A2
SCHEMBL12950352 0.73 GRM4 (0.38) GRM4CYP2C19MEN1ALDH1A1CYP1A2
SCHEMBL15684140 0.73 CHRM2 (0.36) ALDH1A1CYP1A2CYP2D6
SCHEMBL24174889 0.73 CHRM2 (0.36) ALDH1A1CYP1A2CYP2D6
SCHEMBL17756086 0.73 CHRM2 (0.36) ALDH1A1CYP1A2CYP2D6
SCHEMBL26656187 0.73 CHRM2 (0.36) ALDH1A1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770622-A APPLYING TO WOOD, LEATHER, POLYMERS, PAPER, WATER BAYER AKTIENGESELLSCHAFT (DE) 1998-06-23 US disclosed
US-5739160-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-14 US disclosed
US-5631291-A BACTERICIDES AND FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-05-20 US disclosed