Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE8B | O95263 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29276060 | 0.91 | NR1H2 (0.39) | HSD17B10PDE8BATM | |
| SCHEMBL30673120 | 0.91 | NR1H2 (0.39) | HSD17B10PDE8BATM | |
| SCHEMBL3576321 | 0.88 | HSD17B10 (0.49) | HSD17B10PDE8BSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1467517 | 0.88 | HSD17B10 (0.49) | HSD17B10PDE8BSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6899788 | 0.88 | HSD17B10 (0.49) | HSD17B10PDE8BSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL428028 | 0.84 | HSD17B10 (0.44) | HSD17B10PDE8BSMN1; SMN2ALDH1A1HCRTR2 | |
| SCHEMBL613074 | 0.84 | HSD17B10 (0.44) | HSD17B10PDE8BSMN1; SMN2ALDH1A1HCRTR2 | |
| SCHEMBL27931575 | 0.84 | POLB (0.50) | HSD17B10SMN1; SMN2ALDH1A1HCRTR2MEN1 | |
| SCHEMBL426040 | 0.84 | HSD17B10 (0.44) | HSD17B10PDE8BSMN1; SMN2ALDH1A1HCRTR2 | |
| SCHEMBL7253288 | 0.84 | POLB (0.50) | HSD17B10SMN1; SMN2ALDH1A1HCRTR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |