Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.52 |
| ▸ | TUBB | P07437 | 3/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649187 | 0.85 | EGFR (0.71) | EGFRKDRCSF1RKITRET | |
| Hydrochloric Acid SCHEMBL8645943 | 0.83 | EGFR (0.46) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL8649529 | 0.81 | EGFR (0.44) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL4397644 | 0.77 | KDM4E (0.62) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL8646155 | 0.76 | EGFR (0.54) | EGFRKDRPDGFRBTUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL8648774 | 0.76 | EGFR (0.54) | EGFRKDRPDGFRBTUBB4ATUBB | |
| Hydrochloric Acid SCHEMBL8647933 | 0.73 | EGFR (0.53) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL22407560 | 0.72 | EGFR (0.56) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL9052748 | 0.71 | EGFR (0.75) | EGFRKDRPDGFRBTUBB4ATUBB | |
| SCHEMBL9115430 | 0.71 | EGFR (0.75) | EGFRKDRPDGFRBTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |