Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.59 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.59 |
| ▸ | PDE1A | P54750 | 4/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.58 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
| ▸ | ESRRG | P62508 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656244 | 1.00 | ESR1 (0.61) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL18290928 | 0.93 | CYP19A1 (0.64) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL18284333 | 0.93 | CYP19A1 (0.64) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL8652610 | 0.93 | CYP19A1 (0.64) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL8654417 | 0.90 | ESR1 (0.61) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL8654414 | 0.90 | ESR1 (0.61) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL8652952 | 0.89 | PDE1A (0.60) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL8652956 | 0.89 | PDE1A (0.60) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL8652243 | 0.87 | ESR1 (0.58) | ESR1ESR2CYP19A1CYP3A4CYP1A2 | |
| SCHEMBL10774708 | 0.87 | CYP19A1 (0.74) | ESR1ESR2CYP19A1CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807899-A | Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-09-15 | — | — | US | disclosed |