SCHEMBL8660508

SCHEMBL8660508

Nc1ncnc2c1ncn2C1C=CC(O)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADCY5 O95622 12/20 0.64
AHCY P23526 4/20 0.59
ADORA2A P29274 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9147328 1.00 ADCY5 (0.64) ADCY5AHCYADORA2A
SCHEMBL8885831 0.87 ADORA2A (0.60) ADCY5AHCYADORA2A
SCHEMBL8885990 0.84 ADCY5 (0.46) ADCY5AHCY
SCHEMBL4352091 0.83 ADCY5 (0.45) ADCY5AHCY
SCHEMBL8885246 0.83 ADCY5 (0.45) ADCY5AHCY
SCHEMBL30897109 0.83 ADCY5 (0.45) ADCY5AHCY
SCHEMBL111590 0.82 ADCY5 (0.74) ADCY5AHCYADORA2A
SCHEMBL5997273 0.82 ADCY5 (0.74) ADCY5AHCYADORA2A
SCHEMBL5998483 0.82 ADCY5 (0.74) ADCY5AHCYADORA2A
SCHEMBL5997270 0.82 ADCY5 (0.74) ADCY5AHCYADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5744600-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-04-28 US disclosed
US-5631259-A PURINE BASE DERIVATIVES FOR NUCLEOSIDES HOECHST AKTIENGESELLSCHAFT (DE) 1997-05-20 US disclosed
EP-0369409-B1 Carbocyclic nucleosides and nucleotides ACAD OF SCIENCE CZECH REPUBLIC (CS) 1995-01-04 EP disclosed
EP-0521463-A2 Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents HOECHST AKTIENGESELLSCHAFT (DE) 1993-01-07 EP disclosed
EP-0369409-A1 Carbocyclic nucleosides and nucleotides INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1990-05-23 EP disclosed