SCHEMBL8660726

SCHEMBL8660726

Cc1cc(Oc2ccc(Cl)cc2Cl)c(Cl)c(C)c1NC(=O)NC(=O)c1c(F)cccc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
MAPT P10636 3/20 0.43
USP2 O75604 1/20 0.43
ALOX15 P16050 1/20 0.43
POLB P06746 1/20 0.42
ATM Q13315 1/20 0.40
PNLIP P16233 2/20 0.39
ALDH1A1 P00352 1/20 0.39
ALOX12 P18054 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GCGR P47871 1/20 0.38
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.38
THRB P10828 1/20 0.38
RECQL P46063 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
SCN5A Q14524 1/20 0.38
SCN9A Q15858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8661393 0.94 MEN1 (0.41) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL10752405 0.93 MEN1 (0.47) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8659678 0.93 KMT2A (0.45) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8662516 0.93 KMT2A (0.45) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL9135151 0.92 MEN1 (0.47) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8663091 0.92 MEN1 (0.47) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8658202 0.92 MEN1 (0.47) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8656588 0.91 GCGR (0.42) MEN1KMT2AMAPTPOLBATM
SCHEMBL8658546 0.90 MEN1 (0.43) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8659947 0.90 KMT2A (0.48) MEN1KMT2AMAPTUSP2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215056-A1 PESTICIDAL 1-(4-PHENOXYPHENYL)-3-BENZOYL UREA COMPOUNDS AND PROCESS FOR PREPARATION UNION CARBIDE CORPORATION (US) 1987-03-25 EP claimed
WO-1986005781-A1 PESTICIDAL 1-(4-PHENOXYPHENYL)-3-BENZOYL UREA COMPOUNDS AND PROCESS FOR PREPARATION UNION CARBIDE CORPORATION (US) 1986-10-09 WO claimed
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed