Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 11/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656622 | 0.91 | KDM4E (0.50) | KDM4ENPC1ALDH1A1MAPK1RAF1 | |
| SCHEMBL8662523 | 0.85 | KDM4E (0.50) | KDM4ENPC1ALDH1A1MAPK1RAF1 | |
| SCHEMBL8658035 | 0.84 | S1PR1 (0.49) | KDM4ENPC1ALDH1A1MAPK1RAF1 | |
| SCHEMBL8659552 | 0.82 | KDM4E (0.54) | KDM4ENPC1ALDH1A1MAPK1RAF1 | |
| SCHEMBL8659984 | 0.80 | KDR (0.42) | KDM4ENPC1ALDH1A1MAPK1KDR | |
| SCHEMBL10639537 | 0.80 | NPC1 (0.45) | KDM4ENPC1ALDH1A1MAPK1KDR | |
| SCHEMBL8657623 | 0.79 | KDM4E (0.48) | KDM4ENPC1ALDH1A1MAPK1RAF1 | |
| SCHEMBL7583562 | 0.78 | KDM4E (0.50) | KDM4ENPC1ALDH1A1MAPK1RAF1 | |
| SCHEMBL10635359 | 0.77 | KDM4E (0.49) | KDM4ENPC1ALDH1A1MAPK1KDR | |
| SCHEMBL10635180 | 0.77 | KDM4E (0.42) | KDM4ENPC1ALDH1A1MAPK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776981-A | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| US-5776982-A | Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals | NOVARTIS CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| US-5420163-A | Insecticides or miticides | CIBA-GEIGY (US) | 1995-05-30 | — | — | US | disclosed |
| US-5135953-A | Oral or injections; cattle, swine, poultry | CIBA-GEIGY (US) | 1992-08-04 | — | — | US | disclosed |
| US-4659724-A | Certain 1-[4-(5-cyano-2-pyridyloxy)phenyl-benzoyl ureas having pesticidal properties | UNION CARBIDE CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |
| EP-0211004-A1 | USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS | RHONE-POULENC NEDERLAND B.V. (NL) | 1987-02-25 | — | — | EP | disclosed |
| WO-1986003941-A1 | USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS | UNION CARBIDE CORPORATION (US) | 1986-07-17 | — | — | WO | disclosed |
| EP-0115210-A1 | Pesticidal benzoyl ureas and process for their preparation | UNION CARBIDE CORPORATION (US) | 1984-08-08 | — | — | EP | disclosed |