SCHEMBL8661386

SCHEMBL8661386

O=C(NC(=O)c1ccccc1Cl)Nc1ccc(Oc2ccc(Cl)cc2Cl)cc1

nearest known ligand 0.87

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.87
PNLIP P16233 12/20 0.71
TDP1 Q9NUW8 1/20 0.61
PYGL P06737 4/20 0.55
STK39 Q9UEW8 2/20 0.53
PARG Q86W56 1/20 0.52
NPC1 O15118 1/20 0.51
POLB P06746 1/20 0.51
PKM P14618 1/20 0.51
RAB9A P51151 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11133152 0.91 GCGR (0.76) GCGRPNLIPTDP1PYGLNPC1
SCHEMBL11141724 0.88 GCGR (0.87) GCGRPNLIPTDP1PYGLSTK39
SCHEMBL11138798 0.88 GCGR (0.78) GCGRPNLIPTDP1PYGLSTK39
SCHEMBL8659897 0.86 GCGR (0.72) GCGRPNLIPTDP1STK39
SCHEMBL9325879 0.84 GCGR (0.69) GCGRPNLIPTDP1STK39
SCHEMBL11138391 0.84 TDP1 (0.70) GCGRPNLIPTDP1PYGLSTK39
SCHEMBL11388824 0.83 GCGR (0.62) GCGRPNLIPTDP1PYGLNPC1
SCHEMBL11301231 0.83 GCGR (0.77) GCGRPNLIPTDP1NPC1PKM
SCHEMBL8660805 0.83 GCGR (0.61) GCGRPNLIPTDP1PYGLNPC1
Chlorbenzuron SCHEMBL5177776 0.82 GCGR (0.68) GCGRTDP1PYGLNPC1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
US-4399152-A Substituted benzoyl ureas as insecticides DUPHAR INTERNATIONAL B.V. (NL) 1983-08-16 US disclosed