Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 19/20 | 0.71 |
| ▸ | HTR1B | P28222 | 19/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805258 | 0.88 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL8659017 | 0.86 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL4338862 | 0.84 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8649478 | 0.84 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7471152 | 0.83 | HTR1D (0.73) | HTR1DHTR1BHTR1AHTR2C | |
| SCHEMBL8662011 | 0.83 | HTR1D (0.82) | HTR1DHTR1B | |
| SCHEMBL9077790 | 0.83 | HTR1D (0.68) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL4578716 | 0.80 | HTR1D (0.63) | HTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL4346229 | 0.79 | HTR2C (0.72) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL7473789 | 0.79 | HTR1D (0.77) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |