Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 9/20 | 0.39 |
| ▸ | CDC7 | O00311 | 4/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | STK3 | Q13188 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664696 | 0.76 | LIMK1 (0.39) | ERAP1LIMK1CDC7CDK5RET | |
| SCHEMBL31167649 | 0.65 | PSMB8 (0.36) | ERAP1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4745018 | 0.64 | ERAP1 (1.00) | ERAP1LIMK1RETPI4KAPI4K2B | |
| SCHEMBL23001542 | 0.62 | MAPK1 (0.34) | LIMK1CDK5RETAURKAKDR | |
| SCHEMBL6993509 | 0.60 | LIMK1 (0.42) | LIMK1CDC7CDK5RETPLK4 | |
| SCHEMBL8662852 | 0.57 | LIMK1 (0.46) | LIMK1CDC7CDK5RETPLK4 | |
| SCHEMBL18312205 | 0.56 | IKBKB (0.53) | LIMK1CDC7CDK5RETPLK4 | |
| SCHEMBL1718947 | 0.56 | — | — | |
| SCHEMBL42313 | 0.55 | ADORA2A (0.42) | ERAP1RETMAP4K4PI4KAPI4K2B | |
| SCHEMBL24500015 | 0.55 | LIMK1 (0.47) | LIMK1CDC7CDK5RETPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636372-B1 | Antiviral, antitumor, antimetastatic, immune system enhancing 7-thia-guanosine derivatives | ICN PHARMACEUTICALS (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0348446-B1 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES | UNIV BRIGHAM YOUNG (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0636372-A1 | Antiviral, antitumor, antimetastatic, immune system enhancing 7-thia-guanosine derivatives | BRIGHAM YOUNG UNIVERSITY (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0348446-A4 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES | — | 1991-09-25 | — | — | EP | disclosed |
| US-5041426-A | Viricides, antitumor agents | BRIGHAM YOUNG UNIVERSITY (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0348446-A1 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES. | UNIV BRIGHAM YOUNG (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4880784-A | ANTITUMOR AGENTS | BRIGHAM YOUNG UNIVERSITY (US) | 1989-11-14 | — | — | US | disclosed |
| WO-1989005649-A1 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES | BRIGHAM YOUNG UNIVERSITY (US) | 1989-06-29 | — | — | WO | disclosed |