Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 5/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191104 | 0.88 | PPARG (0.51) | GNRHR | |
| SCHEMBL6986887 | 0.87 | GNRHR (0.51) | GNRHR | |
| SCHEMBL6983015 | 0.86 | CXCR2 (0.55) | CYP2C9 | |
| SCHEMBL6984508 | 0.86 | GNRHR (0.49) | GNRHR | |
| SCHEMBL8185257 | 0.85 | GNRHR (0.49) | GNRHRKDM4EALDH1A1 | |
| SCHEMBL8668503 | 0.85 | MAPT (0.43) | GNRHRMTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL6982073 | 0.85 | GNRHR (0.47) | GNRHR | |
| SCHEMBL6983351 | 0.84 | GNRHR (0.51) | GNRHR | |
| SCHEMBL8697833 | 0.83 | GNRHR (0.43) | GNRHR | |
| SCHEMBL6982574 | 0.82 | GNRHR (0.48) | GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871624-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997021703-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |