SCHEMBL8666516

SCHEMBL8666516

C=CCOC(=O)c1ccccc1C(=O)c1ccccc1C(=O)O

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.77
ALDH1A1 P00352 5/20 0.62
TSHR P16473 2/20 0.62
HSD17B10 Q99714 2/20 0.62
AKR1C3 P42330 1/20 0.46
ALOX15 P16050 1/20 0.45
CDC25B P30305 3/20 0.44
RHOA P61586 1/20 0.43
PKM P14618 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
CYP2C9 P11712 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalic Acid SCHEMBL23929049 0.95 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Benzene SCHEMBL7689916 0.95 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Phthalic Acid SCHEMBL710708 0.95 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Phthalic Acid SCHEMBL710707 0.95 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
SCHEMBL87635 0.95 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Ammonia Solution, Strong SCHEMBL29144165 0.93 CYP3A4 (0.83) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Hydrochloric Acid SCHEMBL10627992 0.93 CYP3A4 (0.83) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Bicarbonate SCHEMBL20838539 0.93 CYP3A4 (0.83) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
SCHEMBL28193530 0.93 CYP3A4 (0.83) CYP3A4ALDH1A1TSHRHSD17B10ALOX15
Naphthalene SCHEMBL28123359 0.90 CYP3A4 (0.77) CYP3A4ALDH1A1TSHRHSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880503-A1 BALANOL ANALOGUES Phytera Symbion ApS (DK) 1998-12-02 EP disclosed
WO-1997029091-A1 BALANOL ANALOGUES PHYTERA SYMBION APS (DK) 1997-08-14 WO disclosed