SCHEMBL8667

SCHEMBL8667

Cc1cccc2[nH]cnc12

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.56
BRD4 O60885 2/20 0.45
CBFB Q13951 1/20 0.41
DRD4 P21917 3/20 0.40
DRD3 P35462 3/20 0.40
MGAM O43451 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
PRNP P04156 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
DRD2 P14416 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28915576 0.98 PARP1 (0.55) PARP1BRD4CBFBDRD4DRD3
SCHEMBL20828600 0.83 BRD4 (0.51) PARP1BRD4MGAMGAASI
SCHEMBL20878376 0.77 BRD4 (0.56) PARP1BRD4DRD4DRD3MEN1
SCHEMBL3171067 0.76 PARP1 (0.52) PARP1BRD4DRD4DRD3MEN1
SCHEMBL1261706 0.74 PARP1 (0.55) PARP1BRD4DRD4DRD3MEN1
SCHEMBL900151 0.74 MEN1 (0.52) PARP1BRD4DRD4DRD3MEN1
SCHEMBL312427 0.74 PARP1 (0.56) PARP1BRD4DRD4DRD3GAA
SCHEMBL3157571 0.74 PARP1 (0.50) PARP1BRD4DRD4DRD3MEN1
SCHEMBL2884811 0.74 PARP1 (0.56) PARP1BRD4DRD4DRD3MEN1
SCHEMBL13857864 0.74 PARP1 (0.50) PARP1BRD4DRD4DRD3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2321 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119563048-A Passivation coating on copper metal surfaces for copper wire bonding applications 北德克萨斯大学 2025-03-04 CN claimed
WO-2024201393-A1 METHODS FOR THE SYNTHESIS OF NUCLEOSIDE ANALOGUES AND NUCLEOSIDES ANALOGUES DERIVED THEREFROM SIMON FRASER UNIVERSITY (CA) 2024-10-03 WO claimed
US-20240254546-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION AMPLIWISE INC. (US) 2024-08-01 US claimed
EP-4090768-B1 COMPOSITIONS, KITS AND METHODS FOR ISOLATING TARGET POLYNUCLEOTIDES DNAE DIAGNOSTICS LTD (GB) 2024-03-13 EP claimed
CN-111788183-B Heterocyclic fused phenyl compounds useful for inhibiting TNIK and medical uses thereof 韩国化学硏究院 2024-02-23 CN claimed
US-11827925-B2 Compositions and methods for nucleic acid amplification AMPLIWISE INC. (US) 2023-11-28 US claimed
CN-117106189-A Metal organic framework artificial hydrolase and preparation method and application thereof 华南理工大学 2023-11-24 CN claimed
EP-3749647-B1 N-(5-(PHENYL)-1H-PYRAZOL-3-YL)-1H-INDOL-5-AMINE DERIVATIVES AS TNIK INHIBITORS FOR THE TREATMENT OF CANCER KOREA RES INST CHEMICAL TECH (KR) 2023-09-27 EP claimed
CN-116606685-A Water-soluble temper rolling liquid composition for non-degreased annealed steel sheet 大同化学株式会社 2023-08-18 CN claimed
CN-114457145-B Linkers, constructs, methods and uses for characterizing target polynucleotide sequencing 成都齐碳科技有限公司 2023-08-11 CN claimed
US-20150038554-A1 Extended Dicer Substrate Agents and Methods for the Specific Inhibition of Gene Expression NOVO NORDISK A/S (DK) 2015-02-05 US claimed
US-20130041010-A1 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA CONTAINING MODIFIED NUCLEOTIDES DICERNA PHARMACEUTICALS, INC. (US) 2013-02-14 US claimed
US-20110288147-A1 Compositions and methods for the specific inhibition of gene expression by DSRNA containing a tetraloop DICERNA PHARMACEUTICALS, INC. 2011-11-24 US claimed
EP-2341943-A2 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA POSSESSING MODIFICATIONS Dicerna Pharmaceuticals, Inc. (US) 2011-07-13 EP claimed
WO-2011033235-A1 COMPOSITE MATERIAL COMPRISING AN ORGANIC-INORGANIC MATERIAL, PREPARATION PROCESS, AND USES TREDI (FR) 2011-03-24 WO claimed
US-20100331389-A1 Compositions and methods for the specific inhibition of gene expression by dsRNA containing modified nucleotides DICERNA PHARMACEUTICALS, INC. 2010-12-30 US claimed
WO-2010033225-A2 COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA POSSESSING MODIFICATIONS DICERNA PHARMACEUTICALS, INC. (US) 2010-03-25 WO claimed
EP-2091929-A1 AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS The European Molecular Biology Laboratory (DE) 2009-08-26 EP claimed
CN-101421257-A Agents that disrupt cellular replication and their use in inhibiting pathological conditions EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE) 2009-04-29 CN claimed
WO-2007107352-A1 AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) 2007-09-27 WO claimed