Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 13/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 12/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14518797 | 0.88 | HSD17B2 (0.57) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL29940269 | 0.88 | HSD17B2 (0.57) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL20264436 | 0.82 | HSD17B2 (0.52) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL28392555 | 0.82 | HSD17B2 (0.55) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL20264380 | 0.81 | HSD17B2 (0.53) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL29940268 | 0.81 | HSD17B2 (0.53) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL11027897 | 0.79 | HSD17B2 (0.61) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL20264517 | 0.79 | HSD17B2 (0.61) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL10940468 | 0.78 | HSD17B2 (0.60) | HSD17B2HSD17B1MTNR1AMTNR1B | |
| SCHEMBL9956630 | 0.78 | HSD17B2 (0.60) | HSD17B2HSD17B1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726323-A | COMPOUNDS USEFUL FOR ALLEVIATING MEMORY DYSFUNCTIONS | HOECHST MARION ROUSSEL, INC. | 1998-03-10 | — | — | US | disclosed |
| US-5591864-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS WHICH ALLEVIATE MEMORY DYSFUNCITONS | HOECHST MARION ROUSSEL, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0484573-B1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5260452-A | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0484573-A1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-13 | — | — | EP | disclosed |
| US-5081117-A | Treatment of memory dysfunctions such as in Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-14 | — | — | US | disclosed |