⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21785045 | 0.96 | CRBN (0.47) | — | |
| SCHEMBL31059 | 0.96 | — | — | |
| SCHEMBL9058472 | 0.96 | CRBN (0.47) | — | |
| Calcium SCHEMBL29977738 | 0.92 | — | — | |
| SCHEMBL32662853 | 0.92 | — | — | |
| Water SCHEMBL29871097 | 0.92 | CRBN (0.44) | — | |
| Ammonia Solution, Strong SCHEMBL8471093 | 0.92 | CRBN (0.44) | — | |
| Bromide SCHEMBL19411899 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL5740143 | 0.92 | CRBN (0.44) | — | |
| SCHEMBL2672858 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974782-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170216275-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-08-03 | — | — | US | disclosed |
| US-9422242-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150080394-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | COLUMBIA UNIVERSITY (US) | 2015-03-19 | — | — | US | disclosed |
| EP-2379076-B1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | UNIV COLUMBIA (US) | 2014-11-12 | — | — | EP | disclosed |
| US-8697875-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-04-15 | — | — | US | disclosed |
| US-20120076732-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-03-29 | — | — | US | disclosed |
| EP-2379076-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010074783-A1 | PHOSPHODIESTERASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20060167010-A1 | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds | BEYONDSPRING PHARMACEUTICALS, INC. | 2006-07-27 | — | — | US | disclosed |
| US-7026322-B2 | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds | NEREUS PHARMACEUTICALS, INC. (US) | 2006-04-11 | — | — | US | disclosed |
| WO-2005011699-A1 | PHENYLAHISTIN AND THE PHENYLAHISTIN ANALOGS, A NEW CLASS OF ANTI-TUMOR COMPOUNDS | NEREUS PHARMACEUTICALS, INC. (US) | 2005-02-10 | — | — | WO | disclosed |
| US-20040102454-A1 | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds | BEYONDSPRING PHARMACEUTICALS, INC. | 2004-05-27 | — | — | US | disclosed |
| US-6713480-B2 | ADMINISTERING TO VERTEBRATE AN EFFECTIVE TUMOR-GROWTH-INHIBITING PHENYLAHISTIN COMPOUND OR PRODRUG ESTER FOR THERAPY OF CANCER | NEREUS PHARMACEUTICALS INC. | 2004-03-30 | — | — | US | disclosed |
| US-20020143021-A1 | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds | NEREUS PHARMACEUTICALS, INC. | 2002-10-03 | — | — | US | disclosed |
| US-6358957-B1 | CANCER THERAPY | NEREUS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-5338845-A | Analgesics, antiinflammatory agent | STERLING WINTHROP INC. (US) | 1994-08-16 | — | — | US | disclosed |
| US-4007190-A | ANTITUMOR, MICROBIOCIDE | MERCK & CO., INC. (US) | 1977-02-08 | — | — | US | disclosed |