Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 13/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.43 |
| ▸ | BHMT | Q93088 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL8671844 | 1.00 | GRIK1 (0.52) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL5538695 | 0.92 | GRIK1 (0.59) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL5538692 | 0.92 | GRIK1 (0.59) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Serine SCHEMBL5338147 | 0.89 | GRIK1 (0.50) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL28066305 | 0.89 | SLC1A1 (0.54) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL108340 | 0.89 | SLC1A1 (0.54) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL108339 | 0.89 | SLC1A1 (0.54) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Serine SCHEMBL850904 | 0.89 | GRIK1 (0.50) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL9716104 | 0.86 | SLC7A5 (0.50) | GRIK1GRIK2SLC1A1GRM1GRM2 | |
| Aspartic Acid SCHEMBL3442616 | 0.86 | SLC7A5 (0.50) | GRIK1GRIK2SLC1A1GRM1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705350-A | Transcription factor complexes in senescent cells | DUKE UNIVERSITY (US) | 1998-01-06 | — | — | US | disclosed |