SCHEMBL8674547

SCHEMBL8674547

COc1cc2ncnc(N3CCN(C(=S)Nc4ccc(-c5csnn5)cc4)CC3)c2cc1OC

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 20/20 0.71
PDGFRA P16234 3/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2947467 0.90 PDGFRB (0.73) PDGFRBPDGFRA
SCHEMBL2923606 0.84 PDGFRB (0.81) PDGFRBPDGFRA
SCHEMBL2923468 0.83 PDGFRB (0.85) PDGFRBPDGFRA
SCHEMBL2920909 0.83 PDGFRB (1.00) PDGFRBPDGFRA
SCHEMBL2919396 0.83 PDGFRB (0.80) PDGFRBPDGFRA
SCHEMBL2918698 0.82 PDGFRB (1.00) PDGFRBPDGFRA
SCHEMBL2921248 0.82 PDGFRB (1.00) PDGFRBPDGFRA
SCHEMBL2913997 0.82 PDGFRB (1.00) PDGFRBPDGFRA
SCHEMBL2922796 0.82 PDGFRB (1.00) PDGFRBPDGFRA
SCHEMBL2924140 0.82 PDGFRB (1.00) PDGFRBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882717-A1 NITROGENOUS HETEROCYCLIC COMPOUNDS KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1998-12-09 EP disclosed