Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.46 |
| ▸ | AKT2 | P31751 | 14/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869458 | 0.83 | AKT1 (0.51) | AKT1AKT2 | |
| SCHEMBL539495 | 0.70 | AKT1 (0.55) | AKT1AKT2 | |
| SCHEMBL868168 | 0.68 | AKT1 (0.56) | AKT1AKT2 | |
| SCHEMBL538490 | 0.67 | AKT1 (0.53) | AKT1 | |
| SCHEMBL866809 | 0.66 | AKT1 (0.57) | AKT1 | |
| SCHEMBL539275 | 0.65 | AKT1 (0.60) | AKT1AKT2 | |
| SCHEMBL538245 | 0.64 | AKT1 (0.52) | AKT1AKT2 | |
| SCHEMBL538520 | 0.64 | AKT1 (0.65) | AKT1AKT2 | |
| SCHEMBL360941 | 0.63 | AKT1 (1.00) | AKT1AKT2 | |
| SCHEMBL868878 | 0.63 | AKT1 (0.53) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077810-A1 | Inhibitors Of AKT Activity | MERCK SHARP & DOHME LLC | 2012-03-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077810-A1 | Inhibitors Of AKT Activity | PIK3CA, PIK3CD, PIK3CB | AKT1 11/4885AKT2 7/4885ALDH1A1 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.