Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444779 | 0.98 | TSHR (0.44) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL8674655 | 0.98 | TSHR (0.44) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL17471358 | 0.86 | TSHR (0.43) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL7603128 | 0.84 | TSHR (0.37) | TSHRMAPK1KMT2ACHRM2CHRM4 | |
| SCHEMBL9609345 | 0.84 | TSHR (0.44) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL23652285 | 0.82 | TSHR (0.36) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL9615708 | 0.80 | DPP4 (0.42) | TSHRMAPK1CHRM2CHRM4CHRM1 | |
| SCHEMBL873507 | 0.79 | TSHR (0.50) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL11170830 | 0.79 | TSHR (0.50) | TSHREPHX1MAPK1MEN1KMT2A | |
| SCHEMBL1051503 | 0.79 | TSHR (0.50) | TSHREPHX1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783602-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |