SCHEMBL8675376

SCHEMBL8675376

CC1=Cc2c(-c3cnc4ccccc4c3)cccc2C1[Zr](C1C=Cc2ccccc21)[SiH](C)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.33
CREBBP Q92793 2/20 0.33
PDGFRB P09619 1/20 0.30
PDGFRA P16234 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8675236 0.81 BRD4 (0.38) BRD4CREBBPPDGFRBPDGFRA
SCHEMBL8675857 0.75 BRD4 (0.32) BRD4CREBBP
SCHEMBL8675796 0.74 BRD4 (0.33) BRD4CREBBP
SCHEMBL7050089 0.73 BRD4 (0.30) BRD4
SCHEMBL8679081 0.72 BRD4 (0.34) BRD4CREBBPPDGFRBPDGFRA
SCHEMBL8679024 0.71 PARP10 (0.35) BRD4CREBBPPDGFRBPDGFRA
Hydrochloric Acid SCHEMBL8679084 0.70 BRD4 (0.35) BRD4CREBBPPDGFRBPDGFRA
Hydrochloric Acid SCHEMBL7562463 0.70 BRD4 (0.36) BRD4CREBBPPDGFRBPDGFRA
SCHEMBL8675379 0.70 BRD4 (0.33) BRD4CREBBPPDGFRBPDGFRA
Hydrochloric Acid SCHEMBL8675798 0.70 BRD4 (0.33) BRD4CREBBPPDGFRBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840947-A Organometallic compound TARGOR GMBH (DE) 1998-11-24 US claimed