Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | FLT1 | P17948 | 5/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.63 |
| ▸ | EGFR | P00533 | 10/20 | 0.61 |
| ▸ | ILK | Q13418 | 8/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | BUB1 | O43683 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8684910 | 0.99 | KDR (0.62) | KDRFLT1FGFR1EGFRILK | |
| SCHEMBL8685042 | 0.83 | EGFR (0.70) | KDRFLT1FGFR1EGFRILK | |
| Hydrochloric Acid SCHEMBL8688061 | 0.82 | EGFR (0.68) | KDRFLT1FGFR1EGFRILK | |
| SCHEMBL8682991 | 0.79 | EGFR (0.64) | KDRFLT1FGFR1EGFRILK | |
| SCHEMBL8687775 | 0.79 | EGFR (0.64) | KDRFLT1FGFR1EGFRILK | |
| Hydrochloric Acid SCHEMBL8688101 | 0.78 | EGFR (0.63) | KDRFLT1FGFR1EGFRILK | |
| Hydrochloric Acid SCHEMBL8688108 | 0.78 | EGFR (0.63) | KDRFLT1FGFR1EGFRILK | |
| SCHEMBL7864807 | 0.78 | KDR (1.00) | KDRFLT1FGFR1EGFRILK | |
| Hydrochloric Acid SCHEMBL18297957 | 0.77 | EGFR (0.71) | KDRFLT1FGFR1EGFRILK | |
| SCHEMBL8688053 | 0.77 | EGFR (0.61) | KDRFLT1FGFR1EGFRILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747498-A | Alkynyl and azido-substituted 4-anilinoquinazolines | PFIZER INC. (US) | 1998-05-05 | — | — | US | claimed |
| US-5747498-A | Alkynyl and azido-substituted 4-anilinoquinazolines | PFIZER INC. (US) | 1998-05-05 | — | — | US | disclosed |