Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.58 |
| ▸ | AURKA | O14965 | 5/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.49 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 4/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | FRK | P42685 | 4/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868249 | 0.76 | EIF2AK3 (0.46) | KDREPHB4EIF2AK3 | |
| SCHEMBL14033752 | 0.75 | EPHB4 (0.62) | KDRAURKBEPHB4EIF2AK3EIF2AK1 | |
| Hydrochloric Acid SCHEMBL869114 | 0.75 | EIF2AK3 (0.45) | KDREPHB4EIF2AK3 | |
| SCHEMBL31060331 | 0.74 | KDR (1.00) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3531281 | 0.74 | KDR (1.00) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3529631 | 0.74 | KDR (0.59) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL28803622 | 0.72 | KDR (0.79) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL4471357 | 0.72 | EPHB4 (1.00) | KDRAURKAAURKBEPHB4EIF2AK3 | |
| SCHEMBL17165793 | 0.72 | KDR (0.77) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL3530681 | 0.72 | KDR (0.59) | KDRAURKAAURKBEPHB4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| CN-102917588-B | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-08 | — | — | CN | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885AURKA 2503/4885AURKB 2752/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885AURKA 2503/4885AURKB 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.