Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | NAT1 | P18440 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810704 | 1.00 | PARP1 (0.60) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8810616 | 0.90 | PARP1 (0.58) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8810612 | 0.90 | PARP1 (0.58) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8811252 | 0.87 | TTR (0.53) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8690488 | 0.87 | TTR (0.53) | PARP1MEN1KMT2ATTRAKR1B1 | |
| SCHEMBL8810709 | 0.86 | MEN1 (0.52) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1250153 | 0.79 | MEN1 (0.77) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1250156 | 0.79 | MEN1 (0.77) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL12891816 | 0.79 | MEN1 (0.77) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8685347 | 0.77 | TTR (0.55) | PARP1MEN1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |