Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 14/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685670 | 1.00 | HPGD (0.53) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8685641 | 0.91 | HPGD (0.53) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8685637 | 0.91 | HPGD (0.53) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8690599 | 0.89 | NPC1 (0.54) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8690603 | 0.89 | NPC1 (0.54) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8685678 | 0.87 | KDM4C (0.42) | HPGD | |
| SCHEMBL14406530 | 0.81 | PIM1 (0.49) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL8685065 | 0.80 | PIM1 (0.53) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8685061 | 0.80 | PIM1 (0.53) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL8685615 | 0.78 | PARP1 (0.56) | HPGDPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |