Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809748 | 1.00 | PARP1 (0.72) | PARP1PTPN1HPGDPOLBMAOA | |
| SCHEMBL1248859 | 0.90 | PARP1 (0.83) | PARP1HPGDPOLBKDM4EMEN1 | |
| SCHEMBL12891974 | 0.90 | PARP1 (0.83) | PARP1HPGDPOLBKDM4EMEN1 | |
| SCHEMBL1248861 | 0.90 | PARP1 (0.83) | PARP1HPGDPOLBKDM4EMEN1 | |
| SCHEMBL8810516 | 0.89 | HPGD (0.61) | PARP1PTPN1HPGDPOLBMAOA | |
| SCHEMBL8688092 | 0.89 | HPGD (0.61) | PARP1PTPN1HPGDPOLBMAOA | |
| SCHEMBL8809753 | 0.89 | PARP1 (0.56) | PARP1PTPN1HPGDPOLBMAOA | |
| SCHEMBL8812776 | 0.85 | PARP1 (0.82) | PARP1HPGDPOLBMEN1ALDH1A1 | |
| SCHEMBL8688578 | 0.85 | PARP1 (0.82) | PARP1HPGDPOLBMEN1ALDH1A1 | |
| SCHEMBL8688039 | 0.84 | PARP1 (1.00) | PARP1HPGDPOLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |