Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC10A2 | Q12908 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884719 | 0.80 | WHR1 (0.41) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL8886056 | 0.76 | WHR1 (0.44) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL8735327 | 0.75 | WHR1 (0.41) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL8637407 | 0.75 | PDE4A (0.41) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL7819852 | 0.75 | WHR1 (0.48) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL8138601 | 0.74 | WHR1 (0.42) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL8884725 | 0.72 | WHR1 (0.41) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| Diethylamine SCHEMBL8136070 | 0.72 | PDE4A (0.56) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL8884921 | 0.71 | KDM4E (0.48) | WHR1L3MBTL1PDE4APDE4DKDM4E | |
| SCHEMBL7825968 | 0.70 | WHR1 (0.46) | WHR1L3MBTL1PDE4APDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |