Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686376 | 1.00 | PARP1 (0.67) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL1248861 | 0.88 | PARP1 (0.83) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL12891974 | 0.88 | PARP1 (0.83) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL1248859 | 0.88 | PARP1 (0.83) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL8685615 | 0.87 | PARP1 (0.56) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL8685612 | 0.87 | PARP1 (0.56) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL8686377 | 0.86 | PARP1 (0.50) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL12892101 | 0.85 | PARP1 (0.62) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL1250177 | 0.85 | PARP1 (0.62) | PARP1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL1250179 | 0.85 | PARP1 (0.62) | PARP1MEN1KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |