Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KPNA2 | P52292 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8686384 | 1.00 | PARP1 (0.61) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL1249238 | 0.90 | KMT2A (0.66) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL1249239 | 0.90 | KMT2A (0.66) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL12892091 | 0.90 | KMT2A (0.66) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL8685879 | 0.87 | TTR (0.51) | PARP1KMT2AALDH1A1MEN1TTR | |
| SCHEMBL8685882 | 0.87 | TTR (0.51) | PARP1KMT2AALDH1A1MEN1TTR | |
| SCHEMBL8686391 | 0.87 | KMT2A (0.51) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL12892101 | 0.83 | PARP1 (0.62) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL1250177 | 0.83 | PARP1 (0.62) | PARP1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL1250179 | 0.83 | PARP1 (0.62) | PARP1KMT2AALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811439-A | ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS | SENGA PHARMACEUTICAL LABORATORY INC. (JP) | 1998-09-22 | — | — | US | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |