Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24358640 | 0.77 | MAP2K4 (0.51) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL2671233 | 0.77 | MAP2K4 (0.51) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL7665062 | 0.77 | KDM4E (0.37) | KMT2AMEN1ATML3MBTL1KDM4E | |
| SCHEMBL3603266 | 0.73 | MAP2K4 (0.52) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL12269661 | 0.72 | MAP2K4 (0.42) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL15687750 | 0.72 | MAP2K4 (0.48) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL15687283 | 0.72 | MAP2K4 (0.48) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL31750236 | 0.71 | MAP2K4 (0.56) | MAP2K4KIF11NPC1KMT2APARP1 | |
| SCHEMBL2671565 | 0.71 | MAP2K4 (0.59) | MAP2K4KIF11NPC1KMT2AMEN1 | |
| SCHEMBL30159687 | 0.71 | MAP2K4 (0.56) | MAP2K4KIF11NPC1PARP1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |