⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149072 | 0.81 | — | — | |
| SCHEMBL1149082 | 0.79 | — | — | |
| SCHEMBL10948770 | 0.70 | — | — | |
| SCHEMBL11478475 | 0.69 | — | — | |
| SCHEMBL30466385 | 0.69 | — | — | |
| SCHEMBL11136711 | 0.62 | — | — | |
| SCHEMBL449201 | 0.60 | — | — | |
| SCHEMBL6416766 | 0.60 | — | — | |
| SCHEMBL25124445 | 0.58 | — | — | |
| SCHEMBL1998298 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 916 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025133395-A1 | BICYCLIC (HETERO)ARYLENE WRN INHIBITORY COMPOUNDS | FORX THERAPEUTICS AG (CH) | 2025-06-26 | — | — | WO | claimed |
| EP-4551555-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS | Vividion Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | claimed |
| CN-119677716-A | Pharmaceutical compositions comprising WRN helicase inhibitors | 维维迪恩医疗公司 | 2025-03-21 | — | — | CN | claimed |
| US-20240262834-A1 | SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-08-08 | — | — | US | claimed |
| US-20240140915-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS | VIVIDION THERAPEUTICS, INC. | 2024-05-02 | — | — | US | claimed |
| EP-4347599-A1 | SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF | Merck Sharp & Dohme LLC (US) | 2024-04-10 | — | — | EP | claimed |
| US-20240067612-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS | VIVIDION THERAPEUTICS, INC. | 2024-02-29 | — | — | US | claimed |
| CN-117500806-A | Synthesis of BTK inhibitors and intermediates thereof | 默沙东有限责任公司 | 2024-02-02 | — | — | CN | claimed |
| WO-2024010782-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS | VIVIDION THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | claimed |
| WO-2022251404-A1 | SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF | MERCK SHARP & DOHME LLC (US) | 2022-12-01 | — | — | WO | claimed |
| CN-102458581-A | N- (hetero) aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo [2,3-d ] pyrimidines and pyrrol-3-yl-pyrrolo [2,3-d ] pyrimidines as JANUS kinase inhibitors | INCYTE CORP | 2012-05-16 | — | — | CN | claimed |
| US-20100300939-A1 | Process for Removing a Contaminant from an Aromatic Selective Solvent | UOP LLC (US) | 2010-12-02 | — | — | US | claimed |
| US-20100270213-A1 | EXTRACTIVE DISTILLATION PROCESS AND SYSTEM | UOP LLC | 2010-10-28 | — | — | US | claimed |
| EP-1009738-B1 | SUBSTITUTED OXINDOLE DERIVATIVES AS PROTEIN TYROSINE KINASE AND AS PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2004-05-19 | — | — | EP | claimed |
| EP-0530537-B1 | Condensed pyrimidine derivatives, their production and use as antitumor agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-01-08 | — | — | EP | claimed |
| EP-0530537-A1 | Condensed pyrimidine derivatives, their production and use as antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-10 | — | — | EP | claimed |
| EP-0492316-A1 | Condensed heterocyclic oligoglutamate derivatives, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1992-07-01 | — | — | EP | claimed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | claimed |
| US-4187231-A | Cyanide-catalyzed isomerization and deuterium exchange with alpha- and beta-sulfolenes | PHILLIPS PETROLEUM COMPANY (US) | 1980-02-05 | — | — | US | claimed |
| US-4053369-A | EXTRACTIVE DISTILLATION | PHILLIPS PETROLEUM COMPANY (US) | 1977-10-11 | — | — | US | claimed |