Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.72 |
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675157 | 0.85 | FGFR1 (0.77) | FGFR1HPGDALDH1A1 | |
| SCHEMBL2570944 | 0.84 | FGFR1 (1.00) | FGFR1HPGDGSK3BSMN1; SMN2NPC1 | |
| SCHEMBL6875300 | 0.84 | FGFR1 (0.76) | FGFR1HPGDGSK3BSMN1; SMN2NPC1 | |
| SCHEMBL2650058 | 0.84 | FGFR1 (0.76) | FGFR1HPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL23675303 | 0.80 | FGFR1 (0.77) | FGFR1HPGDGSK3BSMN1; SMN2KMT2A | |
| SCHEMBL2647587 | 0.79 | FGFR1 (0.68) | FGFR1HPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6752611 | 0.78 | FGFR1 (0.67) | FGFR1HPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2650843 | 0.78 | FGFR1 (0.67) | FGFR1HPGDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4502855 | 0.78 | FGFR1 (0.79) | FGFR1HPGDGSK3BMAPK1KMT2A | |
| SCHEMBL13305004 | 0.77 | KIT (0.58) | FGFR1HPGDGSK3BMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |